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''Clostridium septicum'' is a gram positive, spore forming, obligate anaerobic bacterium. ''Clostridium septicum'' can cause gas gangrene, but unlike other Clostridium species like ''Clostridium perfringens'', no trauma is necessary at the site of the infection. It is thought that the infection is established by hematogenous spread from the gastrointestinal tract. Gas gangrene caused by ''Clostridium septicum'' is associated with colorectal cancer and other defects of the bowel.〔 ''Clostridium septicum'' causes myonecrosis through the release of exotoxins such as the alpha toxin, lethal toxin, and hemolytic toxin 〔 ==General and Morphological Information== ''C. septicum'' is a large, gram-positive, rod-shaped bacterium that is a member of the normal gut flora in humans as well as other animals.〔 ''C. septicum'' are spore formers, with a terminal spore that gives them their drumstick-like shape.〔 They are also motile bacteria, using peritrichous flagellae to navigate from one environment to the next.〔 ''C. septicum'' are fermentative anaerobes and therefore can live off of a variety of substrates like sugars, amino acids and other organic compounds, generating molecular hydrogen gas and carbon dioxide as byproducts of cellular respiration.〔 Although non-pathogenic, ''C. septicum'' can cause infection quickly if the gut tissue becomes necrotic or inflamed.〔 ''C. septicum'' produces four toxins; alpha, beta, gamma and delta, with alpha toxin being necrotic and lethal.〔 Their anaerobic nature creates susceptibility in areas of decreased blood flow.〔 Although rare, ''C. septicum'' infections are often found in individuals with a recent history of trauma, surgery, peripheral vascular disease, diabetes, colon cancer, skin infections or burns and septic abortions.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Clostridium septicum」の詳細全文を読む スポンサード リンク
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